VACCINES & IMMUNOLOGY
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1. IMMUNITY — TYPES
- Innate Immunity: Born with it, non-specific
- Acquired Immunity: Developed after exposure
- Active Immunity: Body produces own antibodies
- Passive Immunity: Ready-made antibodies given
- Natural Immunity: After recovering from disease
- Artificial Immunity: Through vaccination
2. KEY TERMS
- Antigen: Foreign substance that triggers immune response
- Antibody: Protein produced to fight antigen
- Vaccine: Weakened/dead pathogen to trigger immunity
- Serum: Contains ready-made antibodies
- Herd Immunity: When majority is immune, disease can't spread
- Booster Dose: Extra dose to strengthen immunity
3. IMPORTANT VACCINES & DISCOVERERS
- Smallpox → Vaccinia → Edward Jenner
- Rabies → Rabies vaccine → Louis Pasteur
- Polio → OPV/IPV → Jonas Salk / Albert Sabin
- TB → BCG → Calmette & Guerin
- Cholera → Cholera vaccine → Louis Pasteur
- Typhoid → TAB vaccine
- Hepatitis B → HBV vaccine
- COVID-19 → Covishield, Covaxin
- Measles → MMR
- HPV → Gardasil
4. NATIONAL IMMUNIZATION PROGRAMME
- BCG → Birth
- OPV (Polio) → Birth, 6, 10, 14 weeks
- Hepatitis B → Birth
- DPT → 6, 10, 14 weeks
- Measles → 9 months
- MMR → 15 months
- Typhoid → 2 years
DPT = Diphtheria + Pertussis + Tetanus
5. TYPES OF VACCINES
- Live Attenuated: BCG, OPV, MMR
- Killed/Inactivated: IPV, Cholera, Typhoid
- Toxoid: Tetanus, Diphtheria
- Subunit: Hepatitis B, HPV
- mRNA: Pfizer, Moderna (COVID)
6. IMPORTANT ONE-LINERS
- First vaccine in world → Smallpox (Edward Jenner, 1796)
- Father of Immunology → Edward Jenner
- Father of Microbiology → Louis Pasteur
- BCG = Bacillus Calmette-Guerin
- OPV = Oral Polio Vaccine
- IPV = Inactivated Polio Vaccine
- India's first indigenous COVID vaccine → Covaxin
- Universal Immunization Programme launched → 1985
- Mission Indradhanush launched → 2014
7. MCQ PRACTICE
Q1. Who discovered Smallpox vaccine?
A) Louis Pasteur B) Edward Jenner✅ C) Jonas Salk D) Robert Koch
Q2. BCG vaccine is used against?
A) Cholera B) Polio C) Tuberculosis✅ D) Typhoid
Q3. Which vaccine uses mRNA technology?
A) Covaxin B) BCG C) Pfizer-BioNTech✅ D) OPV
Q4. DPT vaccine covers which diseases?
A) Dengue, Polio, Typhoid
B) Diphtheria, Pertussis, Tetanus✅
C) Dysentery, Plague, Tuberculosis
D) None
Q5. Herd immunity means?
A) Animals are immune
B) Majority population is immune✅
C) Only children are immune
D) Immunity from herbs